Now showing items 1-16 of 16

    • Olivero, Pablo; Leiva Salcedo, Elías; Devoto, Luigi; Stutzin Schottlander, Andrés (ENDOCRINE SOC, 2008-09)
      Chloride permeability pathways and progesterone (P4) secretion elicited by human chorionic gonadotropin (hCG) in human granulosa cells were studied by electrophysiological techniques and single-cell volume, membrane ...
    • Olivero, Pablo; Leiva Salcedo, Elías; Devoto, Luigi; Stutzin Schottlander, Andrés (2008)
      Chloride permeability pathways and progesterone (P4) secretion elicited by human chorionic gonadotropin (hCG) in human granulosa cells were studied by electrophysiological techniques and single-cell volume, membrane potential ...
    • Cerda, Oscar; Cáceres, Mónica; Park, Kang Sik; Leiva Salcedo, Elías; Romero, Aníbal; Varela, Diego; Trimmer, James S.; Stutzin Schottlander, Andrés (Springer Verlag, 2015)
      © 2014, Springer-Verlag Berlin Heidelberg. Transient receptor potential melastatin-like 4 (TRPM4) is a Ca<sup>2+</sup>-activated non-selective cation channel expressed in a wide range of human tissues. TRPM4 ...
    • Cerda Arancibia, Óscar; Cáceres Lluch, Mónica; Park, Kang-Sik; Leiva Salcedo, Elías; Romero, Aníbal; Varela Lekanda, Diego; Trimmer, James S.; Stutzin Schottlander, Andrés (Springer, 2015)
      Transient receptor potential melastatin-like 4 (TRPM4) is a Ca2+-activated non-selective cation channel expressed in a wide range of human tissues. TRPM4 participates in a variety of physiological processes such as T cell ...
    • Gómez, Christian; Acuña Castillo, Claudio; Pérez Núñez, Claudio; Leiva Salcedo, Elías; Riquelme, Denise; Ordenes, Gamaliel; Oshima, Kiyoko; Aravena, Mauricio; Pérez, Viviana I.; Nishimura, Sumiyo; Sabaj Diez, Valeria; Walter, Robin Ann; Sierra, Felipe (GERONTOLOGICAL SOC AMER, 2008-12)
      Aging is associated with a deterioration of the acute phase response to inflammatory challenges. However, the nature of these defects remains poorly defined. We analyzed the hepatic inflammatory response after intraperitoneal ...
    • Acuña Castillo, Claudio; Vidal, Mabel; Inostroza Molina, Ailen; Vallejos Vidal, Eva; Luraschi, Roberto; Figueroa, Maximiliano; Barrera Avalos, Carlos; Vera, Rodrigo; Vargas, Sergio; Valdés, Daniel; Maisey, Kevin; Imarai, Mónica; Leiva Salcedo, Elías; Escobar Álvarez, Alejandro Felipe; Reyes Cerpa, Sebastián; Gaete Silva, Alexis Ignacio; Palma Vejares, Ricardo Fernando; Travisany Flores, Dante Felipe; Rojo, Leonel E.; Reyes López, Felipe E.; Sandino, Ana María (Hindawi, 2022)
      The identification and tracking of SARS-CoV-2 infected patients in the general population are essential components of the global strategy to limit the COVID-19 viral spread, specifically for maintaining traceability and ...
    • Simon, Felipe; Leiva Salcedo, Elías; Armisen Yáñez, Ricardo; Riveros, Ana; Cerda, Oscar; Varela, Diego; Eguiguren, Ana Luisa; Olivero, Pablo; Stutzin Schottlander, Andrés (2010)
      Necrosis is associated with an increase in plasma membrane permeability, cell swelling, and loss of membrane integrity with subsequent release of cytoplasmic constituents. Severe redox imbalance by overproduction of reactive ...
    • Barrera Ávalos, Carlos Esteban; Díaz, Ximena; Madrid, Sebastián; Michelson, Sofía A.; Robles Planells, Claudia Julieta; Sánchez Guerrero, Giselle; Ahumada, Viviana; Mella Torres, Andrea Jesús; Rojo, Leonel E.; Imarai Bahamonde, Mónica; Milla, Luis A.; Leiva Salcedo, Elías; Murgas, Paola; Fernández, Ricardo; Escobar, Alejandro; Acuña Castillo, Claudio (Hindawi, 2021)
      Active immunotherapy against cancer is based on immune system stimulation, triggering efficient and long-lasting antigen-specific immune responses. Immunization strategies using whole dead cells from tumor tissue, containing ...
    • Leiva Salcedo, Elías; Coddou, Claudio; Rodríguez, Felipe; Penna, Antonello; López, Ximena; Neira, Tanya; Fernández, Ricardo; Imarai, Mónica; Rios, Miguel; Escobar, Jorge; Montoya, Margarita; Huidobro Toro, Juan; Escobar, Alejandro; Acuña Castillo, Claudio (2011)
      The purinergic P2X7 receptor (P2X7R) plays an important role during the immune response, participating in several events such as cytokine release, apoptosis, and necrosis. The bacterial endotoxin lipopolysaccharide (LPS) ...
    • Varela Lekanda, Diego; Penna, Antonello; Simon, Felipe; Eguiguren Ossa, Ana; Leiva Salcedo, Elías; Cerda, Oscar; Sala, Francisco; Stutzin Schottlander, Andrés (2010-03-05)
      Volume-sensitive outwardly rectifying (VSOR) Cl channels are critical for the regulatory volume decrease (RVD) response triggered upon cell swelling. Recent evidence indicates that H2O2 plays an essential role in the ...
    • Barrera Ávalos, Carlos; Briceño, Pedro; Valdés, Daniel; Imarai, Mónica; Leiva Salcedo, Elías; Rojo, Leonel E.; Milla, Luis A.; Huidobro Toro, Juan Pablo; Robles Planells, Claudia; Escobar Álvarez, Alejandro; Di Virgilio, Francesco; Morón, Gabriel; Sauma Mahaluf, Daniela Macarena; Acuña Castillo, Claudio (Cell, 2021)
      T cell activation requires the processing and presentation of antigenic peptides in the context of a major histocompatibility complex (MHC complex). Cross -dressing is a non-conventional antigen presentation mechanism, ...
    • Aravena, Mauricio; Pérez, C.; Pérez, V.; Acuña Castillo, Claudio; Gómez, Christian; Leiva Salcedo, Elías; Nishimura, Sumiyo; Sabaj, B.; Walter, Robin Ann (ELSEVIER SCI IRELAND LTD, 2005-03)
      T-kininogen (T-KG) is a precursor of T-kinin, the most abundant kinin in rat serum, and also acts as a strong and specific cysteine proteinase inhibitor. Its expression is strongly induced during aging in rats, and expression ...
    • Pérez, Viviana; Leiva Salcedo, Elías; Acuña Castillo, Claudio; Aravena, Mauricio; Gómez, Christian; Sabaj Diez, Valeria; Colombo, Alicia; Nishimura, Sumiyo; Pérez Núñez, Claudio; Walter, Robin Ann; Sierra, Felipe (ELSEVIER, 2006-03)
      Basal proliferation of endothelial cells increases with age, and this might play a role in the etiology of age-related vascular diseases, as well as angiogenesis. Serum kininogen levels increase during aging in rats and ...
    • Acuña Castillo, Claudio; Aravena, Mauricio; Leiva Salcedo, Elías; Pérez, Viviana; Gómez, Christian; Sabaj Diez, Valeria; Nishimura, Sumiyo; Pérez Núñez, Claudio; Colombo, Alicia; Walter, Robin Ann; Sierra, Felipe (ELSEVIER, 2005-12)
      Plasma levels of kininogens increase with age in both rats and humans. Kininogens are inhibitors of cysteine proteinases, and filarial cysteine proteinase inhibitors (cystatins) reduce the proliferation of T cells. We ...
    • Riquelme, Denise; Cerda Arancibia, Oscar Alejandro; Leiva Salcedo, Elías (Frontiers Media, 2021)
      TRPM4 is a non-selective cation channel activated by intracellular calcium and permeable to monovalent cations. This channel participates in the control of neuronal firing, neuronal plasticity, and neuronal death. TRPM4 ...
    • Cáceres Lluch, Mónica; Ortiz, Liliana; Recabarren, Tatiana; Romero, Aníbal; Colombo Flores, Alicia; Leiva Salcedo, Elías; Varela Lekanda, Diego; Rivas, José; Silva, Ian; Morales, Diego; Campusano, Camilo; Almarza, Óscar; Simon, Felipe; Toledo Araya, Héctor; Park, Kang-Sik; Trimmer, James S.; Cerda, Óscar (Public Library Science, 2015)
      Cellular migration and contractility are fundamental processes that are regulated by a variety of concerted mechanisms such as cytoskeleton rearrangements, focal adhesion turnover, and Ca2+ oscillations. TRPM4 is a ...